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KMID : 0359319860260010109
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Korean Journal of Veterinary Research
1986 Volume.26 No. 1 p.109 ~ p.115
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Immunobiological Studies in Mice Treated with Chemical Carcinogen , 3 - Methylcholanthrene
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Abstract
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Experiments were performed on mice to investigate the effects of a polycyclic aromatic hydrocarbon, 3-methylcholanthrene (MCA) on Arthus reaction, delayed-type hypersensitivity (DTH) and antibody production to sheep red blood cells (SRBC). Mice were sensitized iv with 0.l㎖ of 1% SRBC suspension were treated with a single ip injection of olive oil alone or with different doses of MCA in oil (0.5∼50㎎/Kg) at various time before (-) or after (+) sensitization (day 0) and were challenged at 4 days after SRBC. Arthus reaction was measured at 3 hours after challenge and other responses at 24 hours.
Treatment with MCA inhibited Arthus reaction and DTH to SRBC, measured by footpad swelling reaction, and this immunosuppressing effect was dependent on the dose and time of MGA treatment in relation to SRBC sensitization.
Humoral immune responses as measured by serum hemagglutinin-and hemolysin-titers to SRBC were significantly depressed when MCA was injected before or at the same time of sensitization. However, the response was slightly depressed when injected after SRBC.
These results indicate that MCA suppress the function of the cells involved in immune responses.
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